Human (Homo sapiens)

Top 500 InterPro hits

No.	InterPro name	Number of genes	Number of Ensembl hits	No.	InterPro name	Number of genes	Number of Ensembl hits
1	IPR007110 Immunoglobulin-like	941	5945	251	IPR000873 AMP-dependent synthetase/ligase	31	187
2	IPR017452 GPCR, rhodopsin-like superfamily	788	1287	252	IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain	31	118
3	IPR007087 Zinc finger, C2H2	785	26340	253	IPR018316 Tubulin/FtsZ, 2-layer sandwich domain	31	210
4	IPR000276 GPCR, rhodopsin-like, 7TM	781	7917	254	IPR013767 PAS fold	31	158
5	IPR015880 Zinc finger, C2H2-like	781	19347	255	IPR000421 Coagulation factor 5/8 C-terminal type domain	31	586
6	IPR003599 Immunoglobulin subtype	592	5953	256	IPR000301 Tetraspanin, subgroup	31	442
7	IPR013106 Immunoglobulin V-set	564	1497	257	IPR002967 Delta tubulin	31	434
8	IPR000719 Protein kinase, catalytic domain	497	4443	258	IPR006026 Peptidase, metallopeptidase	31	66
9	IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain	489	4846	259	IPR022755 Zinc finger, double-stranded RNA binding	31	113
10	IPR002290 Serine/threonine- / dual-specificity protein kinase, catalytic domain	487	1927	260	IPR004046 Glutathione S-transferase, C-terminal	31	81
11	IPR000725 Olfactory receptor	477	2897	261	IPR003604 Zinc finger, U1-type	31	272
12	IPR020635 Tyrosine-protein kinase, catalytic domain	470	1759	262	IPR001173 Glycosyl transferase, family 2	31	81
13	IPR001909 Krueppel-associated box	416	3373	263	IPR000467 G-patch domain	30	299
14	IPR001841 Zinc finger, RING-type	355	2173	264	IPR001315 Caspase Recruitment	30	317
15	IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx	336	528	265	IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular	30	171
16	IPR013151 Immunoglobulin	330	1540	266	IPR000569 HECT	30	318
17	IPR003596 Immunoglobulin V-set, subgroup	312	842	267	IPR001164 Arf GTPase activating protein	30	665
18	IPR003598 Immunoglobulin subtype 2	285	3828	268	IPR002452 Alpha tubulin	30	741
19	IPR001680 WD40 repeat	281	12706	269	IPR000306 Zinc finger, FYVE-type	30	195
20	IPR020683 Ankyrin repeat-containing domain	279	1049	270	IPR002067 Mitochondrial carrier protein	30	364
21	IPR001849 Pleckstrin homology domain	276	3047	271	IPR002353 Type II antifreeze protein	30	307
22	IPR001356 Homeodomain	267	2335	272	IPR006073 GTP binding domain	30	190
23	IPR002110 Ankyrin repeat	263	12984	273	IPR000727 Target SNARE coiled-coil domain	29	272
24	IPR013098 Immunoglobulin I-set	259	3108	274	IPR006594 LisH dimerisation motif	29	202
25	IPR017986 WD40-repeat-containing domain	251	1210	275	IPR001251 CRAL-TRIO domain	29	285
26	IPR018957 Zinc finger, C3HC4 RING-type	232	773	276	IPR020477 C2 domain	29	373
27	IPR018249 EF-HAND 2	231	1444	277	IPR001879 GPCR, family 2, extracellular hormone receptor domain	29	363
28	IPR000504 RNA recognition motif domain	230	4774	278	IPR018159 Spectrin/alpha-actinin	29	1869
29	IPR001452 Src homology-3 domain	226	4836	279	IPR002453 Beta tubulin	29	1071
30	IPR000742 Epidermal growth factor-like domain	218	2766	280	IPR001134 Netrin domain	29	62
31	IPR003597 Immunoglobulin C1-set	210	1440	281	IPR003054 Type II keratin	29	325
32	IPR006210 Epidermal growth factor-like	206	4453	282	IPR017978 GPCR, family 3, C-terminal	29	205
33	IPR001611 Leucine-rich repeat	206	1484	283	IPR002494 Keratin, high sulphur B2	29	53
34	IPR011511 Variant SH3	197	1080	284	IPR000108 Neutrophil cytosol factor 2 p67phox	29	442
35	IPR003961 Fibronectin, type III	192	9796	285	IPR006687 Small GTPase superfamily, SAR1-type	29	76
36	IPR000210 BTB/POZ-like	190	978	286	IPR008824 DNA helicase, Holliday junction RuvB type, N-terminal	28	80
37	IPR003591 Leucine-rich repeat, typical subtype	181	3492	287	IPR006586 ADAM, cysteine-rich	28	158
38	IPR006689 Small GTPase superfamily, ARF/SAR type	176	857	288	IPR023780 Chromo domain	28	122
39	IPR001806 Small GTPase superfamily	176	2739	289	IPR000418 Ets	28	700
40	IPR013684 Mitochondrial Rho-like	173	583	290	IPR001111 Transforming growth factor-beta, N-terminal	28	53
41	IPR005225 Small GTP-binding protein domain	166	488	291	IPR013094 Alpha/beta hydrolase fold-3	28	119
42	IPR003593 AAA+ ATPase domain	161	621	292	IPR000449 Ubiquitin-associated/translation elongation factor EF1B, N-terminal	28	102
43	IPR001478 PDZ domain	152	3757	293	IPR001818 Peptidase M10, metallopeptidase	28	62
44	IPR003579 Small GTPase superfamily, Rab type	151	502	294	IPR001023 Heat shock protein Hsp70	27	653
45	IPR002048 Calcium-binding EF-hand	145	1187	295	IPR004843 Metallophosphoesterase domain	27	118
46	IPR019734 Tetratricopeptide repeat	144	2963	296	IPR011489 EMI domain	27	116
47	IPR013069 BTB/POZ	144	467	297	IPR013787 S100/CaBP-9k-type, calcium binding, subdomain	27	61
48	IPR001881 EGF-like calcium-binding	141	3798	298	IPR001594 Zinc finger, DHHC-type, palmitoyltransferase	27	181
49	IPR013026 Tetratricopeptide repeat-containing domain	140	563	299	IPR002119 Histone H2A	27	252
50	IPR001254 Peptidase S1/S6, chymotrypsin/Hap	139	1205	300	IPR004045 Glutathione S-transferase, N-terminal	27	87
51	IPR020849 Small GTPase superfamily, Ras type	135	440	301	IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal	27	376
52	IPR001870 B30.2/SPRY domain	133	412	302	IPR003560 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase	27	141
53	IPR013162 CD80-like, immunoglobulin C2-set	132	489	303	IPR013126 Heat shock protein 70	27	157
54	IPR014001 Helicase, superfamily 1/2, ATP-binding domain	132	907	304	IPR004753 Cell shape determining protein MreB/Mrl	27	102
55	IPR000008 C2 calcium-dependent membrane targeting	131	1871	305	IPR000620 Drug/metabolite transporter	27	93
56	IPR003877 SPla/RYanodine receptor SPRY	131	376	306	IPR001878 Zinc finger, CCHC-type	27	433
57	IPR000315 Zinc finger, B-box	128	1376	307	IPR003968 Potassium channel, voltage dependent, Kv	27	206
58	IPR001650 Helicase, C-terminal	127	1210	308	IPR000182 GNAT domain	26	148
59	IPR018355 SPla/RYanodine receptor subgroup	127	354	309	IPR008144 Guanylate kinase	26	286
60	IPR001314 Peptidase S1A, chymotrypsin-type	124	932	310	IPR000082 SEA	26	196
61	IPR011701 Major facilitator superfamily	123	408	311	IPR000233 Cadherin, cytoplasmic domain	26	55
62	IPR003578 Small GTPase superfamily, Rho type	123	375	312	IPR005135 Endonuclease/exonuclease/phosphatase	26	122
63	IPR011598 Helix-loop-helix DNA-binding	115	965	313	IPR006053 Tumour necrosis factor alpha/beta/c	26	172
64	IPR002126 Cadherin	113	7396	314	IPR017448 Speract/scavenger receptor-related	26	384
65	IPR018029 C2 membrane targeting protein	112	754	315	IPR020457 Zinc finger, B-box, chordata	26	112
66	IPR000980 SH2 domain	112	2318	316	IPR001190 Speract/scavenger receptor	26	1086
67	IPR005821 Ion transport	110	846	317	IPR013273 Peptidase M12B, ADAM-TS	26	169
68	IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal	107	426	318	IPR018487 Hemopexin/matrixin, repeat	26	335
69	IPR003879 Butyrophylin-like	106	1633	319	IPR002348 Interleukin 1/heparin-binding growth factor	25	250
70	IPR001965 Zinc finger, PHD-type	103	648	320	IPR010294 ADAM-TS Spacer 1	25	56
71	IPR000795 Protein synthesis factor, GTP-binding	101	502	321	IPR006649 Like-Sm ribonucleoprotein (LSM) domain, eukaryotic/archaea-type	25	62
72	IPR006209 EGF-like domain	101	817	322	IPR003954 RNA recognition motif domain, eukaryote	25	158
73	IPR020846 Major facilitator superfamily domain	101	301	323	IPR003034 DNA-binding SAP	25	254
74	IPR020472 G-protein beta WD-40 repeat	94	846	324	IPR021190 Peptidase M10A, matrix metallopeptidase	25	241
75	IPR001660 Sterile alpha motif domain	94	727	325	IPR018933 Netrin module, non-TIMP type	25	100
76	IPR019787 Zinc finger, PHD-finger	93	825	326	IPR000313 PWWP	25	417
77	IPR020479 Homeodomain, metazoa	93	450	327	IPR020454 Diacylglycerol/phorbol-ester binding	25	327
78	IPR021129 Sterile alpha motif, type 1	93	357	328	IPR001163 Like-Sm ribonucleoprotein (LSM) domain	25	65
79	IPR016044 Filament	90	186	329	IPR007235 Glycosyl transferase, family 28, C-terminal	25	46
80	IPR001304 C-type lectin	89	1052	330	IPR021128 MARVEL-like domain	25	79
81	IPR000387 Protein-tyrosine/Dual-specificity phosphatase	89	434	331	IPR018980 FERM, C-terminal PH-like domain	25	121
82	IPR006574 SPRY-associated	89	284	332	IPR001125 Recoverin	25	454
83	IPR007125 Histone core	89	161	333	IPR008145 Guanylate kinase/L-type calcium channel	25	153
84	IPR008160 Collagen triple helix repeat	89	1819	334	IPR020067 Frizzled domain	25	152
85	IPR002035 von Willebrand factor, type A	88	1448	335	IPR000157 Toll/interleukin-1 receptor homology (TIR) domain	25	197
86	IPR001440 Tetratricopeptide TPR-1	87	588	336	IPR019750 Band 4.1 family	25	432
87	IPR011510 Sterile alpha motif, type 2	87	362	337	IPR007502 Helicase-associated domain	24	121
88	IPR000048 IQ motif, EF-hand binding site	87	1592	338	IPR003607 Metal-dependent phosphohydrolase, HD domain	24	103
89	IPR002041 Ran GTPase	85	210	339	IPR001763 Rhodanese-like	24	251
90	IPR000483 Cysteine-rich flanking region, C-terminal	81	307	340	IPR007237 CD20-like	24	102
91	IPR006762 Gtr1/RagA G protein	81	200	341	IPR013655 PAS fold-3	24	105
92	IPR001781 Zinc finger, LIM-type	79	2459	342	IPR013625 Tensin phosphotyrosine-binding domain	24	116
93	IPR001715 Calponin homology domain	77	1442	343	IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase	24	61
94	IPR002198 Short-chain dehydrogenase/reductase SDR	76	633	344	IPR002017 Spectrin repeat	24	1135
95	IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2	75	452	345	IPR009443 Nuclear pore complex interacting	24	353
96	IPR000436 Sushi/SCR/CCP	74	4558	346	IPR001368 TNFR/CD27/30/40/95 cysteine-rich region	24	428
97	IPR006652 Kelch repeat type 1	71	1375	347	IPR000591 DEP domain	23	315
98	IPR001128 Cytochrome P450	71	838	348	IPR006207 Cystine knot, C-terminal	23	96
99	IPR000219 Dbl homology (DH) domain	71	1013	349	IPR002123 Phospholipid/glycerol acyltransferase	23	215
100	IPR002401 Cytochrome P450, E-class, group I	70	1143	350	IPR006028 Gamma-aminobutyric acid A receptor	23	272
101	IPR003439 ABC transporter-like	70	599	351	IPR000834 Peptidase M14, carboxypeptidase A	23	326
102	IPR019955 Ubiquitin supergroup	69	381	352	IPR001876 Zinc finger, RanBP2-type	23	317
103	IPR002347 Glucose/ribitol dehydrogenase	69	790	353	IPR011709 Domain of unknown function DUF1605	23	57
104	IPR000198 Rho GTPase-activating protein domain	69	890	354	IPR017877 Myb-like domain	23	175
105	IPR000884 Thrombospondin, type 1 repeat	68	1939	355	IPR006861 Hyaluronan/mRNA-binding protein	22	27
106	IPR002403 Cytochrome P450, E-class, group IV	67	756	356	IPR002130 Cyclophilin-like peptidyl-prolyl cis-trans isomerase domain	22	440
107	IPR001791 Laminin G domain	67	1854	357	IPR001024 Lipoxygenase, LH2	22	347
108	IPR001039 MHC class I, alpha chain, alpha1/alpha2	67	1025	358	IPR016332 Alpha-1B-glycoprotein/leukocyte immunoglobulin-like receptor	22	45
109	IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding	67	889	359	IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase	22	63
110	IPR003595 Protein-tyrosine phosphatase, catalytic	64	352	360	IPR004841 Amino acid permease domain	22	126
111	IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type	63	2093	361	IPR001159 Double-stranded RNA-binding	22	543
112	IPR013099 Ion transport 2	63	220	362	IPR000408 Regulator of chromosome condensation, RCC1	22	1178
113	IPR013164 Cadherin, N-terminal	63	115	363	IPR000355 Chemokine receptor	22	382
114	IPR000626 Ubiquitin	62	684	364	IPR001526 CD59 antigen	22	72
115	IPR017981 GPCR, family 2-like	62	248	365	IPR002424 Alcohol dehydrogenase, insect-type	22	96
116	IPR018248 EF-hand	62	331	366	IPR002477 Peptidoglycan binding-like	22	42
117	IPR001810 F-box domain, cyclin-like	62	434	367	IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain	22	119
118	IPR011705 BTB/Kelch-associated	62	314	368	IPR000086 NUDIX hydrolase domain	22	66
119	IPR000571 Zinc finger, CCCH-type	62	592	369	IPR003903 Ubiquitin interacting motif	22	481
120	IPR019430 7TM GPCR, serpentine receptor class x (Srx)	61	129	370	IPR002893 Zinc finger, MYND-type	22	197
121	IPR013968 Polyketide synthase, KR	61	144	371	IPR004012 RUN	22	241
122	IPR003959 ATPase, AAA-type, core	61	207	372	IPR013847 POU domain	22	294
123	IPR013105 Tetratricopeptide TPR2	58	187	373	IPR021072 Melanoma associated antigen, MAGE, N-terminal	22	77
124	IPR000353 MHC class II, beta chain, N-terminal	58	380	374	IPR001762 Blood coagulation inhibitor, Disintegrin	21	316
125	IPR013111 EGF, extracellular	58	823	375	IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase	21	90
126	IPR003309 Transcription regulator SCAN	57	552	376	IPR021133 HEAT, type 2	21	258
127	IPR000195 Rab-GTPase-TBC domain	57	534	377	IPR000104 Antifreeze protein, type I	21	99
128	IPR018108 Mitochondrial substrate/solute carrier	56	921	378	IPR000327 POU-specific	21	192
129	IPR000372 Leucine-rich repeat-containing N-terminal	56	375	379	IPR013092 Connexin, N-terminal	21	82
130	IPR007960 Mammalian taste receptor	55	55	380	IPR002659 Glycosyl transferase, family 31	21	39
131	IPR003590 Leucine-rich repeat, ribonuclease inhibitor subtype	55	1625	381	IPR002454 Gamma tubulin	21	463
132	IPR001487 Bromodomain	55	1917	382	IPR000243 Peptidase T1A, proteasome beta-subunit	21	171
133	IPR001623 Heat shock protein DnaJ, N-terminal	54	477	383	IPR000917 Sulfatase	21	83
134	IPR002957 Keratin, type I	54	375	384	IPR003689 Zinc/iron permease	21	92
135	IPR004827 Basic-leucine zipper domain	54	374	385	IPR019605 Misato Segment II, myosin-like	21	49
136	IPR001214 SET domain	54	493	386	IPR010909 PLAC	21	65
137	IPR006935 Helicase/UvrB domain	54	177	387	IPR001060 Fps/Fes/Fer/CIP4 homology	21	296
138	IPR002286 P2 purinoceptor	53	485	388	IPR003953 Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal	21	88
139	IPR005828 General substrate transporter	53	218	389	IPR019570 Gap junction protein, cysteine-rich domain	21	40
140	IPR006020 Phosphotyrosine interaction domain	53	595	390	IPR010579 MHC class I, alpha chain, C-terminal	21	58
141	IPR003131 Potassium channel, voltage dependent, Kv, tetramerisation	52	121	391	IPR000558 Histone H2B	20	168
142	IPR000536 Nuclear hormone receptor, ligand-binding, core	52	495	392	IPR000867 Insulin-like growth factor-binding protein, IGFBP	20	82
143	IPR009071 High mobility group, superfamily	52	748	393	IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain	20	226
144	IPR000832 GPCR, family 2, secretin-like	52	1343	394	IPR003137 Protease-associated domain, PA	20	62
145	IPR019749 Band 4.1 domain	52	237	395	IPR004182 GRAM	20	176
146	IPR001202 WW/Rsp5/WWP	52	1164	396	IPR006553 Leucine-rich repeat, cysteine-containing subtype	20	521
147	IPR000299 FERM domain	51	282	397	IPR002018 Carboxylesterase, type B	20	107
148	IPR001723 Steroid hormone receptor	51	1140	398	IPR009038 GOLD	20	79
149	IPR000859 CUB	51	1623	399	IPR004299 Membrane bound O-acyl transferase, MBOAT	20	83
150	IPR001683 Phox homologous domain	51	477	400	IPR004839 Aminotransferase, class I/classII	20	59
151	IPR001811 Chemokine interleukin-8-like domain	50	168	401	IPR000500 Connexin	20	233
152	IPR001628 Zinc finger, nuclear hormone receptor-type	50	1906	402	IPR007593 Interferon-induced transmembrane protein	20	59
153	IPR000961 AGC-kinase, C-terminal	49	156	403	IPR016293 Peptidase M10A, matrix metallopeptidase, stromelysin type	20	29
154	IPR005834 Haloacid dehalogenase-like hydrolase	49	185	404	IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain	20	175
155	IPR001766 Transcription factor, fork head	49	661	405	IPR015413 Methionyl/Leucyl tRNA synthetase	20	85
156	IPR011497 Protease inhibitor, Kazal-type	49	206	406	IPR001675 Glycosyl transferase, family 29	20	104
157	IPR019748 FERM central domain	48	222	407	IPR000010 Proteinase inhibitor I25, cystatin	20	100
158	IPR019426 7TM GPCR, serpentine receptor class v (Srv)	48	62	408	IPR000095 PAK-box/P21-Rho-binding	20	199
159	IPR011700 Basic leucine zipper	48	169	409	IPR001932 Protein phosphatase 2C-like	20	152
160	IPR000340 Dual specificity phosphatase, catalytic domain	47	145	410	IPR001565 Synaptotagmin	19	239
161	IPR004031 PMP-22/EMP/MP20/Claudin	47	118	411	IPR000433 Zinc finger, ZZ-type	19	286
162	IPR003958 Transcription factor CBF/NF-Y/archaeal histone	47	82	412	IPR019956 Ubiquitin subgroup	19	170
163	IPR001752 Kinesin, motor domain	47	1088	413	IPR023088 3'5'-cyclic nucleotide phosphodiesterase	19	646
164	IPR011616 bZIP transcription factor, bZIP-1	46	167	414	IPR002209 Heparin-binding growth factor/Fibroblast growth factor	19	155
165	IPR000159 Ras-association	46	536	415	IPR001179 Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain	19	218
166	IPR019009 Signal recognition particle receptor, beta subunit	46	113	416	IPR005817 Wnt	19	313
167	IPR000047 Helix-turn-helix motif	46	172	417	IPR013149 Alcohol dehydrogenase, C-terminal	19	61
168	IPR002172 Low-density lipoprotein (LDL) receptor class A repeat	46	1656	418	IPR013517 FG-GAP	19	113
169	IPR000357 HEAT	46	318	419	IPR006552 VWC out	19	117
170	IPR006202 Neurotransmitter-gated ion-channel ligand-binding	46	175	420	IPR000175 Sodium:neurotransmitter symporter	19	595
171	IPR000225 Armadillo	46	2066	421	IPR003118 Pointed domain	19	124
172	IPR024156 Small GTPase superfamily, ARF type	46	113	422	IPR002223 Proteinase inhibitor I2, Kunitz metazoa	19	453
173	IPR001003 MHC class II, alpha chain, N-terminal	45	308	423	IPR004161 Translation elongation factor EFTu/EF1A, domain 2	19	51
174	IPR006029 Neurotransmitter-gated ion-channel transmembrane domain	45	164	424	IPR006208 Cystine knot	19	47
175	IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain	45	150	425	IPR002300 Aminoacyl-tRNA synthetase, class Ia	19	84
176	IPR003095 Heat shock protein DnaJ	44	461	426	IPR000164 Histone H3	19	180
177	IPR000253 Forkhead-associated (FHA) domain	44	511	427	IPR004014 ATPase, P-type cation-transporter, N-terminal	19	168
178	IPR006201 Neurotransmitter-gated ion-channel	44	621	428	IPR006076 FAD dependent oxidoreductase	19	74
179	IPR017096 Kelch-like protein, gigaxonin	44	84	429	IPR007848 Methyltransferase small	19	69
180	IPR010440 Lipopolysaccharide kinase	44	134	430	IPR004148 BAR domain	19	187
181	IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote	43	292	431	IPR015898 G-protein gamma-like domain	19	156
182	IPR017940 ABC transporter, integral membrane type 1	43	198	432	IPR013519 Integrin alpha beta-propellor	19	285
183	IPR001828 Extracellular ligand-binding receptor	43	198	433	IPR023210 NADP-dependent oxidoreductase domain	19	72
184	IPR003659 Plexin/semaphorin/integrin	43	224	434	IPR000533 Tropomyosin	19	342
185	IPR001005 SANT/Myb domain	43	494	435	IPR002164 Nucleosome assembly protein (NAP)	19	73
186	IPR001590 Peptidase M12B, ADAM/reprolysin	42	249	436	IPR015590 Aldehyde dehydrogenase domain	19	104
187	IPR000608 Ubiquitin-conjugating enzyme, E2	41	344	437	IPR004853 Domain of unknown function DUF250	18	48
188	IPR014014 RNA helicase, DEAD-box type, Q motif	41	222	438	IPR002575 Aminoglycoside phosphotransferase	18	64
189	IPR000073 Alpha/beta hydrolase fold-1	41	257	439	IPR000798 Ezrin/radixin/moesin family	18	393
190	IPR013216 Methyltransferase type 11	40	116	440	IPR010456 Ribosomal L11 methyltransferase, PrmA	18	66
191	IPR011498 Kelch repeat type 2	40	176	441	IPR008646 Herpesvirus UL45-like	18	39
192	IPR001496 SOCS protein, C-terminal	40	336	442	IPR011016 Zinc finger, RING-CH-type	18	54
193	IPR011704 ATPase, dynein-related, AAA domain	40	134	443	IPR003124 WH2 domain	18	147
194	IPR000611 Neuropeptide Y receptor	40	322	444	IPR006212 Furin-like repeat	18	273
195	IPR002870 Peptidase M12B, propeptide	40	129	445	IPR001508 NMDA receptor	18	268
196	IPR001609 Myosin head, motor domain	40	1024	446	IPR003594 ATPase-like, ATP-binding domain	18	81
197	IPR001140 ABC transporter, transmembrane domain	39	190	447	IPR001320 Ionotropic glutamate receptor	18	151
198	IPR006052 Tumour necrosis factor	39	201	448	IPR017923 Transcription factor IIS, N-terminal	18	41
199	IPR002397 Cytochrome P450, B-class	39	403	449	IPR001194 DENN	18	218
200	IPR007111 NACHT nucleoside triphosphatase	39	169	450	IPR000904 SEC7-like	18	153
201	IPR008250 ATPase, P-type, ATPase-associated domain	38	156	451	IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase	18	267
202	IPR001509 NAD-dependent epimerase/dehydratase	38	97	452	IPR013649 Integrin alpha-2	18	57
203	IPR001757 ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter	38	1007	453	IPR001638 Extracellular solute-binding protein, family 3	18	77
204	IPR004087 K Homology domain	38	424	454	IPR000413 Integrin alpha chain	18	439
205	IPR017892 Protein kinase, C-terminal	37	119	455	IPR000998 MAM domain	18	501
206	IPR000772 Ricin B lectin domain	37	231	456	IPR012317 Poly(ADP-ribose) polymerase, catalytic domain	18	128
207	IPR002190 MAGE protein	37	226	457	IPR019594 Glutamate receptor, L-glutamate/glycine-binding	18	149
208	IPR001839 Transforming growth factor-beta, C-terminal	37	128	458	IPR013217 Methyltransferase type 12	18	40
209	IPR000863 Sulfotransferase domain	37	107	459	IPR001507 Zona pellucida sperm-binding protein	17	192
210	IPR004088 K Homology domain, type 1	37	860	460	IPR002402 Cytochrome P450, E-class, group II	17	121
211	IPR004020 DAPIN domain	37	382	461	IPR006195 Aminoacyl-tRNA synthetase, class II	17	38
212	IPR000595 Cyclic nucleotide-binding domain	37	466	462	IPR000716 Thyroglobulin type-1	17	286
213	IPR002049 EGF-like, laminin	37	1790	463	IPR001107 Band 7 protein	17	169
214	IPR001353 Proteasome, subunit alpha/beta	36	152	464	IPR013602 Dynein heavy chain, domain-2	17	37
215	IPR013763 Cyclin-like	36	174	465	IPR006068 ATPase, P-type cation-transporter, C-terminal	17	88
216	IPR020422 Dual specificity phosphatase, subgroup, catalytic domain	36	199	466	IPR000717 Proteasome component (PCI) domain	17	141
217	IPR000342 Regulator of G protein signalling	36	721	467	IPR001753 Crotonase, core	17	75
218	IPR006671 Cyclin, N-terminal	36	141	468	IPR005123 Oxoglutarate/iron-dependent oxygenase	17	50
219	IPR023796 Serpin domain	36	327	469	IPR013521 Potassium channel, inwardly rectifying, Kir, conserved region 2	17	275
220	IPR013122 Polycystin cation channel, PKD1/PKD2	36	197	470	IPR003280 Two pore domain potassium channel	17	78
221	IPR000953 Chromo domain/shadow	35	275	471	IPR001699 Transcription factor, T-box	17	458
222	IPR002350 Proteinase inhibitor I1, Kazal	35	298	472	IPR000471 Interferon alpha/beta/delta	17	84
223	IPR013766 Thioredoxin domain	35	159	473	IPR013057 Amino acid transporter, transmembrane	17	93
224	IPR000566 Lipocalin/cytosolic fatty-acid binding protein domain	35	87	474	IPR001610 PAC motif	17	61
225	IPR017455 Zinc finger, FYVE-related	35	130	475	IPR001494 Importin-beta, N-terminal	17	167
226	IPR000203 GPS domain	35	489	476	IPR000248 Angiotensin II receptor	17	244
227	IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit	35	419	477	IPR003974 Potassium channel, voltage dependent, Kv3	17	157
228	IPR018979 FERM, N-terminal	35	164	478	IPR000001 Kringle	17	597
229	IPR015420 Peptidase S1A, nudel	35	75	479	IPR013305 ABC transporter, ABCB2	17	190
230	IPR001895 Guanine-nucleotide dissociation stimulator CDC25	35	481	480	IPR000644 Cystathionine beta-synthase, core	17	312
231	IPR003347 JmjC domain	34	357	481	IPR016449 Potassium channel, inwardly rectifying, Kir	17	34
232	IPR018499 Tetraspanin	34	178	482	IPR001148 Alpha carbonic anhydrase	17	122
233	IPR000330 SNF2-related	34	139	483	IPR004273 Dynein heavy chain	17	55
234	IPR003091 Voltage-dependent potassium channel	34	635	484	IPR022775 AP complex, mu/sigma subunit	17	86
235	IPR001007 von Willebrand factor, type C	34	564	485	IPR000885 Fibrillar collagen, C-terminal	17	232
236	IPR000488 Death	34	297	486	IPR006055 Exonuclease	17	61
237	IPR022617 Small ubiquitin-related modifier, SUMO	33	247	487	IPR005293 Antigen peptide transporter 2	17	39
238	IPR000014 PAS	33	450	488	IPR000679 Zinc finger, GATA-type	17	233
239	IPR003008 Tubulin/FtsZ, GTPase domain	33	280	489	IPR002394 Nicotinic acetylcholine receptor	17	159
240	IPR008625 GAGE	33	65	490	IPR006620 Prolyl 4-hydroxylase, alpha subunit	16	54
241	IPR004000 Actin-like	32	520	491	IPR007951 PMG	16	19
242	IPR002999 Tudor domain	32	409	492	IPR002890 Alpha-2-macroglobulin, N-terminal	16	38
243	IPR000217 Tubulin	32	847	493	IPR003971 Potassium channel, voltage dependent, Kv9	16	173
244	IPR004057 Epsilon tubulin	32	537	494	IPR005112 dDENN	16	194
245	IPR001627 Semaphorin/CD100 antigen	32	408	495	IPR002867 Zinc finger, C6HC-type	16	179
246	IPR006187 Claudin	31	185	496	IPR001846 von Willebrand factor, type D domain	16	211
247	IPR002909 Cell surface receptor IPT/TIG	31	362	497	IPR002928 Myosin tail	16	49
248	IPR002165 Plexin	31	121	498	IPR003655 Krueppel-associated box-related	16	33
249	IPR001357 BRCT domain	31	387	499	IPR013155 Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding	16	46
250	IPR001073 Complement C1q protein	31	476	500	IPR013315 Spectrin alpha chain, SH3 domain	16	173

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